Publications from the past 5 years:
Professor Alan Sinclair
Munshi M, Sy S, Sinclair A, Kahkoska AR, Weinstock R, Cukierman-Yaffe T. Use of Diabetes Technology at the Advanced Age. Diabetes Technol Ther. 2026 Mar;28(2_suppl):168S-179S.
Boccardi V, Sinclair AJ. Hypoglycaemia in Older Adults with Diabetes: Pathophysiology, Prevention, and Personalized Care in an Aging Population. Drugs Aging. 2025 Oct;42(10):921-932;
Maltese G, Sinclair AJ. Older people with type 1 diabetes mellitus: a call for a new management approach. Nat Rev Endocrinol. 2025 Jul;21(7):391-392;
Sinclair A, Al-Banna M, Tutunariu R, Abdelhafiz AH. Personalised Approach to the Management of Older People with Type 2 Diabetes Mellitus-A Comprehensive Narrative Review. J Pers Med. 2026 Apr 13;16(4):213.
Maltese G, Sinclair AJ. Comment on Park et al. Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-Like Peptide 1 Receptor Agonists, and Frailty Progression in Older Adults With Type 2 Diabetes. Diabetes Care 2026;49:147-151. Diabetes Care. 2026 Apr 1;49(4):e73-e74.
Munshi M, Sy S, Sinclair A, Kahkoska AR, Weinstock R, Cukierman-Yaffe T. Use of Diabetes Technology at the Advanced Age. Diabetes Technol Ther. 2026 Mar;28(2_suppl):168S-179S.
Abdelhafiz AH, Siqueira I, Sinclair AJ. Criteria of frail older people with type 2 diabetes who are suitable for SGLT-2 inhibitors and GLP-1RA therapy. J Diabetes Complications. 2025 Dec;39(12):109193.
Maltese G, Kar P, Gallen G, Hicks D, Sinclair AJ. Addressing educational needs in older adults with type 1 diabetes. Lancet Diabetes Endocrinol. 2025 Nov;13(11):909-910.
Boccardi V, Sinclair AJ. Rethinking insulin resistance in aging: A reserve-oriented clinical framework. Ageing Res Rev. 2026 Jul;119:103180. doi: 10.1016/j.arr.2026.103180. Epub 2026 May 17.
Dr Ahmed Abdelhafiz
Abdelhafiz AH, Emmerton D, Sinclair AJ. Impact of frailty metabolic phenotypes on the management of older people with type 2 diabetes mellitus. Geriatr Gerontol Int. 2021 Aug;21(8):614-622.
Sinclair, A.J.; Abdelhafiz, A.H. Multimorbidity, Frailty and Diabetes in Older People–Identifying Interrelationships and Outcomes. J. Pers. Med. 2022, 12, 1911.
Sinclair, A.J., Pennells, D. & Abdelhafiz, A.H. Hypoglycaemic therapy in frail older people with type 2 diabetes mellitus—a choice determined by metabolic phenotype. Aging Clin Exp Res 34, 1949–1967 (2022).
Abdelhafiz AH, Sinclair AJ. Metabolic phenotypes explain the relationship between dysglycaemia and frailty in older people with type 2 diabetes. J Diabetes Complications. 2022 Apr;36(4):108144. doi: 10.1016/j.jdiacomp.2022.108144.
Sinclair, A.J.; Abdelhafiz, A.H. Metabolic Impact of Frailty Changes Diabetes Trajectory. Metabolites 2023, 13, 295.
Abdelhafiz, A.H.; Keegan, G.L.; Sinclair, A.J. Metabolic Characteristics of Frail Older People with Diabetes Mellitus—A Systematic Search for Phenotypes. Metabolites 2023, 13, 705.
Professor Srikanth Bellary
AWAITING LIST
Professor Angus Forbes
Forbes A, Murrells T, Mulnier H, Sinclair AJ. Mean HbA1c, HbA1c variability, and mortality in people with diabetes aged 70 years and older: a retrospective cohort study. Lancet Diabetes Endocrinol. 2018 Jun;6(6):476-486.
Habte-Asres HH, Murrells T, Nitsch D, Wheeler DC, Forbes A. Glycaemic variability and progression of chronic kidney disease in people with diabetes and comorbid kidney disease: Retrospective cohort study. Diabetes Res Clin Pract. 2022 Nov;193:110117.
Habte-Asres HH, Murrells T, Nitsch D, Wheeler DC, Forbes A. Glycaemic variability and progression of chronic kidney disease in people with diabetes and comorbid kidney disease: Retrospective cohort study. Diabetes Res Clin Pract. 2022 Nov;193:110117.
Crosby-Nwaobi RR, Sivaprasad S, Amiel S, Forbes A. The relationship between diabetic retinopathy and cognitive impairment. Diabetes Care. 2013 Oct;36(10):3177-86.
Langerman C, Forbes A, Robert G. A qualitative study of the experiences of insulin use by older people with type 2 diabetes mellitus. BMC Prim Care. 2024 May 22;25(1):180.
Lange Ferreira C, Habte-Asres H, Forbes A. “It is a false safety net”: A qualitative exploration of multiprofessional staff experiences of insulin management in hospitalised older or frail adults with diabetes undergoing surgery. PLoS One. 2025 Oct 7;20(10):e0332088.
Winkley, K. & Forbes, A., 1 Jan 2025, Care of Older People with Diabetes: A Manual for Healthcare Practice. WILEY-BLACKWELL, p. 57-69.
Professor Virginia Boccardi
Boccardi V, Sinclair AJ. Rethinking insulin resistance in aging: A reserve-oriented clinical framework. Ageing Res Rev. 2026 Jul;119:103180. doi: 10.1016/j.arr.2026.103180. Epub 2026 May 17. PMID: 42150705.
Mancinetti F, Guazzarini AG, Gaspari M, Croce MF, Serra R, Mecocci P, Boccardi V. Integrating Nutrition, Inflammation, and Immunity: The CALLY Index as a Novel Prognostic Biomarker in Acute Geriatric Care. Nutrients. 2025 Oct 10;17(20):3192. doi: 10.3390/nu17203192. PMID: 41156445; PMCID: PMC12567162.
Mancinetti F, Xenos D, De Fano M, Mazzieri A, Ercolani S, Mecocci P, Porcellati F, Boccardi V. Switching from insulin injections to degludec/liraglutide in older frail persons: 6-month body composition remodelling. Eur Geriatr Med. 2026 Apr;17(2):977-984. doi: 10.1007/s41999-025-01271-3. Epub 2025 Jul 7. PMID: 40624450.
Inizio modulo
Fine modulo
Boccardi V, Bahat G, Balci C, Bourdel-Marchasson I, Christiaens A, Donini LM, Cavdar S, Maggi S, Özkök S, Pavic T, Perkisas S, Volpato S, Zaidi MS, Zeyfang A, Sinclair AJ. Challenges, current innovations, and opportunities for managing type 2 diabetes in frail older adults: a position paper of the European Geriatric Medicine Society (EuGMS)-Special Interest Group in Diabetes. Eur Geriatr Med. 2025 Aug;16(4):1231-1247. doi: 10.1007/s41999-025-01168-1. Epub 2025 Feb 27. PMID: 40014274; PMCID: PMC12378884.
Boccardi V, Travaglini EG, Sciacca E, Mancinetti F, Murasecco I, Guazzarini AG, Bastiani P, Ruggiero C, Mecocci P. Dysglycemia, gender, and cognitive performance in older persons living with mild cognitive impairment: findings from a cross-sectional, population-based study. Aging Clin Exp Res. 2024 Jul 16;36(1):145. doi: 10.1007/s40520-024-02806-7. PMID: 39012506; PMCID: PMC11252216.
Professor Leocadio Rodriguez Manas
Álvarez-Bustos A, Carnicero JA, Sepúlveda-Loyola W, Garcia-Garcia FJ, Rodríguez-Mañas L. Role of sarcopenia, obesity and sarcopenic obesity in frailty, frailty transitions and death. BMC Geriatr. 2026 Jun 3.
Álvarez-Bustos A, Coelho-Junior HJ, Carnicero JA, Sepúlveda-Loyola W, García-García FJ, Rodriguez-Mañas L. Obesity strengthens the associations between sarcopenia and both frailty and hospitalization, whereas reduces the risk of mortality. J Nutr Health Aging. 2026 Apr;30(4):100803.
Álvarez-Bustos A, Andres-Lacueva C, Ara I, et al. Consensus document on frailty: conceptualization, detection, multidisciplinary management and future roadmap. J Nutr Health Aging. 2026 Mar;30(3):100793.
Marcos-Perez D, Hernandez-Vicente A, Cruces-Salguero S et al., Resistance Exercise Intervention Restores Functional Capacity and Improves Frailty Biomarkers in Centenarians. J Cachexia Sarcopenia Muscle. 2025 Oct;16(5):e70079
Munshi M, Kahkoska AR, Neumiller JJ, et al., Realigning diabetes regimens in older adults: a 4S Pathway to guide simplification and deprescribing strategies. Lancet Diabetes Endocrinol. 2025 May;13(5):427-437.
Laosa O, Topinkova E, Bourdel-Marchasson I, et al., Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study. J Nutr Health Aging. 2025 Apr;29(4):100512.
Sinclair AJ, Laosa O, Antonio Carnicero J, Rodriguez-Mañas L, Álvarez-Bustos A; MIDFRAIL consortium. Disability and Quality of Life Measures in older frail and prefrail people with type 2 diabetes. The MIDFRAIL-Study. Diabetes Res Clin Pract. 2024 Aug;214:111797
Professor Antoine Christiaens